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Tag: Springer

  • Written primarily for those in the food industry concerned with hygiene, the book is also essential background for students and researchers in government and academic institutions.

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  • This text is intended to serve as a basic resource for the student, clinician and researcher. It provides a summary of how we have responded to such violence in the past and presents potential future directions for research and prevention efforts.

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  • Lipid bilayers represent the fundamental model system for biological membranes. In recent years, we have been presented with a wealth of important insights into the structural and functional abilities of lipid bilayers with real possibilities in understanding the complex and varied behaviour of biological membranes. This volume is intended to give the researcher presently in the field and those wishing to enter the field a comprehensive overview into the current state of the art of lipid bilayer research. Detailed reviews are given on such topics as, lipid bilayer structure and dynamics, hydration of lipid bilayers, the role and behaviour of lipid bilayers on fusion and rupture, interaction of lipid bilayers and monolayers with small organic molecules and other additives such as proteins and finally, on the production and characterization of highly aligned bilayers under biologically relevant conditions. The book, besides being a reference, could be used in a graduate level courses with special emphasis in model membrane systems and physical techniques characterization.

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  • Despite considerable scientific and medical effort over the past decades, malaria remains the most important human parasitic disease. It is responsible for up to 3 million deaths and another 300-500 million new cases each year, and is becoming resistant to the current chemoprophylactic and chemotherapeutic agents. In Malaria Methods and Protocols, internationally respected scientists and clinicians describe in step-by-step detail their most useful conventional and cutting-edge techniques for the study of malaria. Areas covered include clinical and laboratory diagnosis and typing, animal models, molecular biology, immunology, cell biology, vaccinology, laboratory models, and field applications. Each readily reproducible protocol has been tested, standardized, and optimized for experimental success, and includes many laboratory notes on troubleshooting, avoiding pitfalls, and interpreting results. Several of the most widely used methods are either described here in detail for the first time or have been thoroughly updated since their original publication (e.g., in vitro culture of Plasmodium parasites and in vitro growth inhibition assay).

    State-of-the-art and highly practical, Malaria Methods and Protocols makes available to basic and applied researchers today’s only comprehensive collection of essential laboratory methods for diagnosing malaria, characterizing the parasite, understanding the interaction between the human host and Plasmodium parasite, and developing effective preventive measures.

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  • Assembly of the basic units of mammalian chromosomes into artificial constructs, and the reduction of their components to more manageable dimensions, has now become a reality. In Mammalian Artificial Chromosomes: Methods and Protocols, leading scientists in cell biology, genetics, cell culturing, and gene transfer present their most productive methods for the preparation, characterization, and use of artificial chromosomes. The authors cover all relevant areas of artificial chromosome research-from basic genetics to daring attempts at building new gene therapy tools-and describe possible applications in genetic manipulation requiring large portions of the genome. Each fully tested protocol is described in step-by-step detail and includes a background introduction outlining the principle behind the technique, reagent and equipment lists, and tips on troubleshooting and how to avoid pitfalls.

    Cutting-edge and much-needed, Mammalian Artificial Chromosomes: Methods and Protocols offers a timely collection of meticulous techniques that will help elucidate the mechanisms of nuclear duplication, allow the introduction of changes into the human genome, and revolutionize our understanding of how chromosomes work.

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  • Climate changes, particularly warming trends, have been recorded around the globe. For many countries, these changes in climate have become evident through insect epidemics (e.g., Mountain Pine Beetle epidemic in Western Canada, bark beetle in secondary spruce forests in Central Europe), water shortages and intense forest fires in the Mediterranean countries (e.g., 2005 droughts in Spain), and unusual storm activities (e.g., the 2004 South-East Asia Tsunami). Climate changes are expected to impact vegetation as manifested by changes in vegetation extent, migration of species, tree species composition, growth rates, and mortality. The International Panel on Climate Change (IPCC) has included discussions on how forests may be impacted, and how they may be used to mitigate the impacts of changes in climate, to possibly slow the rate of change. This book provides current scientific information on the biological and economical impacts of climate changes in forest environments, as well as information on how forest management activities might mitigate these impacts, particularly through carbon sequestration. Case studies from a wide geographic range are presented. This information is beneficial to managers and researchers interested in climate change and impacts upon forest environments and economic activities. This volume, which forms part of Springer’s book series Managing Forest Ecosystems, presents state-of-the-art research results, visions and theories, as well as specific methods for sustainable forest management in changing climatic conditions.

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  • This textbook summarizes the state of the art in this field of research. The topics comprise the examination of sedimentological and physical properties of the sedimentary solid phase, of pore water and pore water constituents, organic matter as the driving force of most microbiological processes, biotic and abiotic redox reactions, carbonates and stable isotopes as proxies for paleoclimate reconstruction, metal enrichments in ferromanganese nodules and crusts as well as in hot vents and cold seeps on the seafloor.

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  • Membrane transporters and channels play key roles in drug absorption and distribution, influence drug efficacy and toxicity, and are the target of about 30% of currently marketed drugs. In Membrane Transporters: Methods and Protocols, a panel of recognized basic and clinical investigators-many world-famous-describe their proven, cutting-edge methodologies for studying these important proteins. Treated in step-by-step detail, these techniques take advantage of all the latest developments in biomedical research, including pharmacogenomics, bioinformatics, and microarray technologies. The authors explain databases and tools for bioinformatics analysis, provide practical guidelines for microarray experiments and data analysis, and illustrate the use of small-angle X-ray scattering, nuclear magnetic resonance (NMR), and molecular modeling to study the structural biology of membrane transporters. Methods for exploring structure-function correlation, such as site-directed mutagenesis, immunocytochemistry, and confocal microscopy, are also described, along with several methods that may help in the development of novel therapeutics. Each technique contains hands-on instructions, many notes on avoiding the problems that one may encounter, and suggestions for variant procedures.

    Comprehensive and highly practical, Membrane Transporters: Methods and Protocols offers investigators working in biopharmaceutical science, drug discovery, and drug delivery both an array of powerful tools for work on membrane transporters and an essential guide to the state-of-the-art in the membrane transporter field today.

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  • Each volume provides the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, with a comprehensive summary and critical overview of a topic of great current interest written by leading international experts.

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  • Many multicellular animals do not require oxygen to live but respire anaerobically. Some of these have adapted to hostile environments, such as sulphide rich habitats, others live as parasites within host organisms, while others still can perhaps be said to look back on the early days of life on earth before anaerobic respiration had evolved.

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  • Microwave technology can significantly reduce sample turnaround times, enhance quality, and reduce hazardous wastes when compared to bench or automated methods. In Microwave Techniques and Protocols, Richard Giberson and Richard Demaree, Jr., have collected a wide range of these time-saving techniques for processing biological samples for evaluation by many different microscopic methods.

    Comprehensive and time saving, Microwave Techniques and Protocols demonstrates for anyone processing biological samples for immunocytochemistry, decalcification, and light or electron microscopy that microwave technology is a critically important tool in all experimental and clinical research laboratories today.

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  • The authors have written an expository text, emphasizing statistical methods and applications rather than the underlying mathematical theory. Analyses of datasets from a range of scientific contexts feature prominently, and simulations are used to illustrate theoretical results. Readers can reproduce most of the computational results in the book by using the authors’ R-based software package, geoR, whose usage is illustrated in a computation section at the end of each chapter.

    The book assumes a working knowledge of classical and Bayesian methods of inference, linear models, and generalized linear models, but does not require previous exposure to spatial statistical models or methods. The authors have used the material in MSc-level statistics courses.

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  • Multimodal Processing and Interaction: Audio, Video and Text covers a broad spectrum of novel perspectives, analytic tools, algorithms, design practices and applications in multimedia science and engineering with emphasis on multimodal integration and modality fusion. This volume also contains contributions in the area of interaction with multimedia, especially multimodal interfaces for accessing multimedia content.

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  • The purpose of Mycotoxin Protocols is to provide the scientific and technological basis for analytical methods for use in obtaining the exposure data needed for risk assessments. Mycotoxin Protocols is divided into four sections, which are interconnected.

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    • Examines the suitability of nanoscale zero-valent iron (ZVI) for degradation of agrochemicals
    • Clarifies the reaction mechanism by which ZVI degrades a chosen contaminant
    • Identifies by-products of the ZVI-mediated degradation process of particular contaminants
    • This is the first book to apply nanotechnology to environmental remediation
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  • It is hoped that Neurobiology of Aggression: Understanding and Preventing Violence will foster further research aimed at understanding the environmental genetic and neurochemical roots of aggression and how such information can be used to move forward towards the goal of eliminating violence.

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